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Target
Acetylcholinesterase
Ligand
BDBM8961
Substrate
n/a
Meas. Tech.
ChEMBL_2112573 (CHEMBL4821423)
IC50
23±n/a nM
Citation
 Pasieka, A; Panek, D; Jończyk, J; Godyń, J; Szałaj, N; Latacz, G; Tabor, J; Mezeiova, E; Chantegreil, F; Dias, J; Knez, D; Lu, J; Pi, R; Korabecny, J; Brazzolotto, X; Gobec, S; Höfner, G; Wanner, K; Więckowska, A; Malawska, B Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters. Eur J Med Chem 218:0 (2021) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ACES_ELEEL | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electric eel
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM8961
Synonyms:
CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2,3,4-tetrahydroacridin-9-amine | Tracine | tacrine.HCl | 9-THA | 1,2,3,4-tetrahydro-9-acridinamine | 9-amino-1,2,3,4-tetrahydroacridine (THA) | Tacrine | US8999994, Tacrine
Type:
Small organic molecule
Emp. Form.:
C13H14N2
Mol. Mass.:
198.12
SMILES:
c1ccc2c(c1)c(c3c(n2)CCCC3)N
Structure:
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