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Target
Transient receptor potential cation channel subfamily M member 5
Ligand
BDBM50571570
Substrate
n/a
Meas. Tech.
ChEMBL_2115166 (CHEMBL4824107)
EC50
891±n/a nM
Citation
 Barilli, A; Aldegheri, L; Bianchi, F; Brault, L; Brodbeck, D; Castelletti, L; Feriani, A; Lingard, I; Myers, R; Nola, S; Piccoli, L; Pompilio, D; Raveglia, LF; Salvagno, C; Tassini, S; Virginio, C; Sabat, M From High-Throughput Screening to Target Validation: Benzo[ J Med Chem 64:5931-5955 (2021) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily M member 5
Synonyms:
LTrpC-5 | Long transient receptor potential channel 5 | Ltrpc5 | MLSN1- and TRP-related gene 1 protein | Mtr1 | Mtr1 GN | Synonyms=Ltrpc5 | TRPM5_MOUSE | Transient receptor potential cation channel subfamily M member 5 | Trpm5
Type:
PROTEIN
Mol. Mass.:
130839.35
Organism:
Mus musculus
Description:
ChEMBL_117216
Residue:
1158
Sequence:
MQTTQSSCPGSPPDTEDGWEPILCRGEINFGGSGKKRGKFVKVPSSVAPSVLFELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGPLCPLDSNLSHFILVESGALGSGNDGLTELQLSLEKHISQQRTGYGGTSCIQIPVLCLLVNGDPNTLERISRAVEQAAPWLILAGSGGIADVLAALVSQPHLLVPQVAEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQARELPIGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAGQKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDLEDLQEPDSLDMEKSFLCSRGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHLSLVLKQVFRKEAQHKRQHLERDLPDPLDQKIITWETVQKENFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSSSQNCGCRSQPASARDREYLESGLPPSDT
  
Inhibitor
Name:
BDBM50571570
Synonyms:
CHEMBL4876211
Type:
Small organic molecule
Emp. Form.:
C12H11ClN4S
Mol. Mass.:
278.761
SMILES:
Cn1c(Cl)cnc1CNc1ccc2sncc2c1
Structure:
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