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Target
Cathepsin K
Ligand
BDBM50137812
Substrate
n/a
Meas. Tech.
ChEBML_45546
IC50
41±n/a nM
Citation
 Catalano, JG; Deaton, DN; Furfine, ES; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Shewchuk, LM; Willard, DH; Wright, LL Exploration of the P1 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett 14:275-8 (2003) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50137812
Synonyms:
((S)-1-Formyl-pent-3-enyl)-carbamic acid tert-butyl ester | CHEMBL96341
Type:
Small organic molecule
Emp. Form.:
C11H19NO3
Mol. Mass.:
213.2735
SMILES:
C\C=C/C[C@H](NC(=O)OC(C)(C)C)C=O
Structure:
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