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Target
Cathepsin K
Ligand
BDBM50137817
Substrate
n/a
Meas. Tech.
ChEBML_45546
IC50
41±n/a nM
Citation
 Catalano, JG; Deaton, DN; Furfine, ES; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Shewchuk, LM; Willard, DH; Wright, LL Exploration of the P1 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett 14:275-8 (2003) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50137817
Synonyms:
CHEMBL92971 | [(S)-1-Formyl-5-(2,2,2-trifluoro-acetylamino)-pentyl]-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C13H21F3N2O4
Mol. Mass.:
326.312
SMILES:
CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)C(F)(F)F)C=O
Structure:
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