Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50137954
Substrate
n/a
Meas. Tech.
ChEBML_215011
IC50
20±n/a nM
Citation
Cho, H; Murakami, K; Nakanishi, H; Fujisawa, A; Isoshima, H; Niwa, M; Hayakawa, K; Hase, Y; Uchida, I; Watanabe, H; Wakitani, K; Aisaka, K Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists. J Med Chem 47:101-9 (2003) [PubMed] Article
More Info.:
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
Inhibitor
Name:
BDBM50137954
Synonyms:
Biphenyl-2-carboxylic acid {4-[8-(2-dimethylamino-ethyl)-5,6,7,8-tetrahydro-1-thia-4,8-diaza-azulene-4-carbonyl]-phenyl}-amide | CHEMBL435331
Type:
Small organic molecule
Emp. Form.:
C31H32N4O2S
Mol. Mass.:
524.676
SMILES:
CN(C)CCN1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccsc12