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Target
2-Hydroxyacid oxidase 1
Ligand
BDBM50572932
Substrate
n/a
Meas. Tech.
ChEMBL_2118567 (CHEMBL4827633)
IC50
1.2±n/a nM
Citation
 Ding, J; Gumpena, R; Boily, MO; Caron, A; Chong, O; Cox, JH; Dumais, V; Gaudreault, S; Graff, AH; King, A; Knight, J; Oballa, R; Surendradoss, J; Tang, T; Wu, J; Lowther, WT; Powell, DA Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria. ACS Med Chem Lett 12:1116-1123 (2021) [PubMed]  Article 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM50572932
Synonyms:
CHEMBL4850573
Type:
Small organic molecule
Emp. Form.:
C33H25F2N7O7S2
Mol. Mass.:
733.721
SMILES:
NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccc(Oc3nn[nH]c3C(O)=O)cc2)-c2nc(cs2)C(O)=O)cc1F
Structure:
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