Found 62 with Last Name = 'lowther' and Initial = 'wt' 
Affinity DataKi: 15nMAssay Description:Inhibition of human glycolate oxidase expressed in Escherichia coli using glycolate as substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 4.50E+3nMAssay Description:Non competitive inhibition of mouse glycolate oxidase in hyperoxaluric-Agxt knockdown mouse primary hepatocyte assessed as reduction in oxalate produ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Competitive inhibition of recombinant human LDHA in the presence of NADH by resazurin dye reduction methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant mouse GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant mouse GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration of compound against renin human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibitory concentration of compound against renin human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of pig HAO1 in presence of NADH by spectrometry analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 136nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 143nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration of compound against renin human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 198nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
Affinity DataIC50: 732nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against renin monkey plasmaMore data for this Ligand-Target Pair
TargetHydroxyproline dehydrogenase [147-515](Homo sapiens (Human))
Wake Forest University Health Sciences
US Patent
Wake Forest University Health Sciences
US Patent
Affinity DataIC50: 2.90E+5nMAssay Description:In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...More data for this Ligand-Target Pair
TargetHydroxyproline dehydrogenase [147-515](Homo sapiens (Human))
Wake Forest University Health Sciences
US Patent
Wake Forest University Health Sciences
US Patent
Affinity DataIC50: 3.20E+5nMAssay Description:In an effort to biochemically and structurally characterize human HYPDH, we have evaluated numerous expression constructs (>15) in Escherichia coli w...More data for this Ligand-Target Pair
