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Target
L-lactate dehydrogenase A chain
Ligand
BDBM50572933
Substrate
n/a
Meas. Tech.
ChEMBL_2118569 (CHEMBL4827635)
IC50
0.200000±n/a nM
Citation
 Ding, J; Gumpena, R; Boily, MO; Caron, A; Chong, O; Cox, JH; Dumais, V; Gaudreault, S; Graff, AH; King, A; Knight, J; Oballa, R; Surendradoss, J; Tang, T; Wu, J; Lowther, WT; Powell, DA Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria. ACS Med Chem Lett 12:1116-1123 (2021) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
L-lactate:NAD+ oxidoreductase A (LDH-A4) | LDHA_MOUSE | Ldh-1 | Ldh1 | Ldha
Type:
Enzyme
Mol. Mass.:
36502.66
Organism:
Mus musculus (Mouse)
Description:
P06151
Residue:
332
Sequence:
MATLKDQLIVNLLKEEQAPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLKTPKIVSSKDYCVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPHCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPELGTDADKEQWKEVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGINEDVFLSVPCILGQNGISDVVKVTLTPEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50572933
Synonyms:
CHEMBL4861379
Type:
Small organic molecule
Emp. Form.:
C33H25F2N7O6S3
Mol. Mass.:
749.787
SMILES:
NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccc(Sc3nn[nH]c3C(O)=O)cc2)-c2nc(cs2)C(O)=O)cc1F
Structure:
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