Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50139028
Substrate
n/a
Meas. Tech.
ChEMBL_106654 (CHEMBL712999)
Ki
1400±n/a nM
Citation
Richardson, TI; Ornstein, PL; Briner, K; Fisher, MJ; Backer, RT; Biggers, CK; Clay, MP; Emmerson, PJ; Hertel, LW; Hsiung, HM; Husain, S; Kahl, SD; Lee, JA; Lindstrom, TD; Martinelli, MJ; Mayer, JP; Mullaney, JT; O'Brien, TP; Pawlak, JM; Revell, KD; Shah, J; Zgombick, JM; Herr, RJ; Melekhov, A; Sampson, PB; King, CH Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor. J Med Chem 47:744-55 (2004) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Inhibitor
Name:
BDBM50139028
Synonyms:
(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-dimethylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-dimethylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide | CHEMBL349850
Type:
Small organic molecule
Emp. Form.:
C32H38ClN5O2
Mol. Mass.:
560.129
SMILES:
CN(C)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1