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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM50574936
Substrate
n/a
Meas. Tech.
ChEMBL_2123711 (CHEMBL4832944)
IC50
0.100000±n/a nM
Citation
 Miah, AH; Smith, IED; Rackham, M; Mares, A; Thawani, AR; Nagilla, R; Haile, PA; Votta, BJ; Gordon, LJ; Watt, G; Denyer, J; Fisher, DT; Dace, P; Giffen, P; Goncalves, A; Churcher, I; Scott-Stevens, P; Harling, JD Optimization of a Series of RIPK2 PROTACs. J Med Chem 64:12978-13003 (2021) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM50574936
Synonyms:
CHEMBL4857880
Type:
Small organic molecule
Emp. Form.:
C53H70N14O7S
Mol. Mass.:
1047.277
SMILES:
[H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)C(=O)c1cnc(cn1)N1CCN(CCCOc2cc3ncnc(Nc4n[nH]c(C)c4C)c3cc2S(=O)(=O)C(C)(C)C)CC1)NC(=O)[C@H](C)NC)C(=O)N[C@@H]1CCCc2ccccc12 |r|
Structure:
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