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Target
Urea transporter 2
Ligand
BDBM50575399
Substrate
n/a
Meas. Tech.
ChEMBL_2125154 (CHEMBL4834499)
IC50
1100±n/a nM
Citation
 Lee, S; Cil, O; Diez-Cecilia, E; Anderson, MO; Verkman, AS Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem 61:3209-3217 (2018) [PubMed]  Article 
Target
Name:
Urea transporter 2
Synonyms:
Slc14a2 | UT2_RAT | Urea transporter 2 | Urea transporter A1 (UT-A1) | Ut2
Type:
Protein
Mol. Mass.:
101906.19
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
929
Sequence:
MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLLTSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETVFPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIKVETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTYPEANRIYFLSQEKNRRASMITKYQAYDVS
  
Inhibitor
Name:
BDBM50575399
Synonyms:
CHEMBL4849280
Type:
Small organic molecule
Emp. Form.:
C23H19N5O4S
Mol. Mass.:
461.493
SMILES:
COc1ccc(C)cc1S(=O)(=O)Nc1ccc(Oc2nc3ccccc3n3cnnc23)cc1
Structure:
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