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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50391358
Substrate
n/a
Meas. Tech.
ChEMBL_2125213 (CHEMBL4834558)
IC50
620±n/a nM
Citation
 Röhrig, UF; Majjigapu, SR; Reynaud, A; Pojer, F; Dilek, N; Reichenbach, P; Ascencao, K; Irving, M; Coukos, G; Vogel, P; Michielin, O; Zoete, V Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. J Med Chem 64:2205-2227 (2021) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50391358
Synonyms:
CHEMBL2147989
Type:
Small organic molecule
Emp. Form.:
C8H6ClN3
Mol. Mass.:
179.606
SMILES:
Clc1cccc(c1)-c1c[nH]nn1
Structure:
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