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Target
DNA nucleotidylexotransferase
Ligand
BDBM50143528
Substrate
n/a
Meas. Tech.
ChEBML_210231
IC50
18000±n/a nM
Citation
 Saito, F; Takeuchi, R; Kamino, T; Kuramochi, K; Sugawara, F; Sakaguchi, K; Kobayashi, S Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases. Bioorg Med Chem Lett 14:1975-7 (2004) [PubMed]  Article 
Target
Name:
DNA nucleotidylexotransferase
Synonyms:
DNA nucleotidylexotransferase | DNTT | TDT | TDT_HUMAN | Terminal addition enzyme | Terminal deoxynucleotidyltransferase | Terminal transferase
Type:
PROTEIN
Mol. Mass.:
58545.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210231
Residue:
509
Sequence:
MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMTGKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCEFRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQLLQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSSWQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKTKRIFLKAESEEEIFAHLGLDYIEPWERNA
  
Inhibitor
Name:
BDBM50143528
Synonyms:
(1S,2S)-2-Hexadecyl-2-methoxymethoxy-5-oxo-cyclopent-3-enecarboxylic acid methyl ester | CHEMBL175179
Type:
Small organic molecule
Emp. Form.:
C25H44O5
Mol. Mass.:
424.6139
SMILES:
CCCCCCCCCCCCCCCC[C@]1(OCOC)C=CC(=O)[C@H]1C(=O)OC |c:21|
Structure:
Search PDB for entries with ligand similarity: