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Found 136 with Last Name = 'sakaguchi' and Initial = 'k'
TargetProtein phosphatase 1D(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50118477(CHEMBL3613748)
Affinity DataKi:  228nMAssay Description:Non-competitive inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416570(CHEMBL1215819)
Affinity DataKi:  750nMAssay Description:Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416568(CHEMBL1215817)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416569(CHEMBL1215818)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416566(CHEMBL1215815)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of nucleotide substrate c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  7.84E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416564(CHEMBL1215813)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109029(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)
Affinity DataKi:  1.28E+4nMAssay Description:Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109029(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)
Affinity DataKi:  2.01E+4nMAssay Description:Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  2.79E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416567(CHEMBL1215816)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 1D(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50118478(CHEMBL3613749)
Affinity DataIC50:  86nMAssay Description:Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 1D(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50361941(CHEMBL1939361)
Affinity DataIC50:  87nMAssay Description:Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 1D(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50118477(CHEMBL3613748)
Affinity DataIC50:  110nMAssay Description:Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 1D(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50118476(CHEMBL3613747)
Affinity DataIC50:  215nMAssay Description:Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Saga University

Curated by ChEMBL
LigandPNGBDBM50481610(CHEMBL609609)
Affinity DataIC50:  290nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Saga University

Curated by ChEMBL
LigandPNGBDBM50481612(CHEMBL596660)
Affinity DataIC50:  300nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Saga University

Curated by ChEMBL
LigandPNGBDBM50481613(CHEMBL597443)
Affinity DataIC50:  360nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein phosphatase 1D(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50361941(CHEMBL1939361)
Affinity DataIC50:  480nMAssay Description:Inhibition of N-terminal histidine-tagged PPM1Dc after 10 mins using BIOMOL GREEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Saga University

Curated by ChEMBL
LigandPNGBDBM50481611(CHEMBL599968)
Affinity DataIC50:  510nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416570(CHEMBL1215819)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded oligo(AGT)12 complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Saga University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assayMore data for this Ligand-Target Pair
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416570(CHEMBL1215819)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded poly-(d-epsilonA) complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184758((3aS,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbo...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50184757((3aR,4R,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184755((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycar...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416568(CHEMBL1215817)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded oligo(AGT)12 complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416561(CHEMBL1215810)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded DNA complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184757((3aR,4R,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50184758((3aS,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbo...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50184756((3aR,4S,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA nucleotidylexotransferase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50184755((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycar...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human TdTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416568(CHEMBL1215817)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded poly-(d-epsilonA) complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA nucleotidylexotransferase(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50143524((3aR,4R,7R,7aS)-3,5-Dihexadecyl-3a,4,7,7a-tetrahyd...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity of the compound against human terminal deoxynucleotidyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416569(CHEMBL1215818)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded oligo(AGT)12 complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416566(CHEMBL1215815)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded oligo(AGT)12 complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50184755((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycar...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184752((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(isopropoxy...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416562(CHEMBL1215811)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded DNA complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184756((3aR,4S,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50184754((E)-methyl-3,6-dioxo-4-docosenoate | CHEMBL425779)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50143526(CHEMBL366792 | Untenone A)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50184752((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(isopropoxy...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique & Universite De Nantes

Curated by ChEMBL
LigandPNGBDBM50416569(CHEMBL1215818)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human RAD51 assessed as dissociation of protein/single-stranded poly-(d-epsilonA) complex formation by fluorescence polarimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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