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Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50576931
Substrate
n/a
Meas. Tech.
ChEMBL_2128506 (CHEMBL4837935)
IC50
239±n/a nM
Citation
 Stanford, SM; Diaz, MA; Ardecky, RJ; Zou, J; Roosild, T; Holmes, ZJ; Nguyen, TP; Hedrick, MP; Rodiles, S; Guan, A; Grotegut, S; Santelli, E; Chung, TDY; Jackson, MR; Bottini, N; Pinkerton, AB Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J Med Chem 64:5645-5653 (2021) [PubMed]  Article 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM50576931
Synonyms:
CHEMBL4870698
Type:
Small organic molecule
Emp. Form.:
C18H12Cl2FN5
Mol. Mass.:
388.226
SMILES:
Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(nc12)-c1cccc(F)c1
Structure:
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