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Target
Capsid scaffolding protein
Ligand
BDBM50143624
Substrate
n/a
Meas. Tech.
ChEMBL_77299 (CHEMBL687228)
IC50
>50±n/a nM
Citation
 Gopalsamy, A; Lim, K; Ellingboe, JW; Mitsner, B; Nikitenko, A; Upeslacis, J; Mansour, TS; Olson, MW; Bebernitz, GA; Grinberg, D; Feld, B; Moy, FJ; O'Connell, J Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors. J Med Chem 47:1893-9 (2004) [PubMed]  Article 
Target
Name:
Capsid scaffolding protein
Synonyms:
APNG | Assemblin | Assembly protein | Capsid protein P40 | Human cytomegalovirus protease (HCMV Pr) | Human herpes virus 5 capsid protein P40 | Protease precursor | SCAF_HCMVA | UL80 | pPR
Type:
PROTEIN
Mol. Mass.:
73854.16
Organism:
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Description:
ChEMBL_158958
Residue:
708
Sequence:
MTMDEQQSQAVAPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAQGQGQPSLSVALPLNINHDDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKVVEFLSGSYAGLSLSSRRCDDVEAATSLSGSETTPFKHVALCSVGRRRGTLAVYGRDPEWVTQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSVDALYIRERLPKLRYDKQLVGVTERESYVKASVSPEAACDIKAASAERSGDSRSQAATPAAGARVPSSSPSPPVEPPSPVQPPALPASPSVLPAESPPSLSPSEPAEAASMSHPLSAAVPAATAPPGATVAGASPAVSSLAWPHDGVYLPKDAFFSLLGASRSAVPVMYPGAVAAPPSASPAPLPLPSYPASYGAPVVGYDQLAARHFADYVDPHYPGWGRRYEPAPSLHPSYPVPPPPSPAYYRRRDSPGGMDEPPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARKRLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASSSPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGPSTAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE
  
Inhibitor
Name:
BDBM50143624
Synonyms:
CHEMBL56020 | N-{5-[(E)-2-(6-Chloro-quinolin-2-yl)-vinyl]-naphthalen-2-yl}-C,C,C-trifluoro-N-methyl-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H16ClF3N2O2S
Mol. Mass.:
476.899
SMILES:
CN(c1ccc2c(\C=C\c3ccc4cc(Cl)ccc4n3)cccc2c1)S(=O)(=O)C(F)(F)F
Structure:
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