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Target
Type-1 angiotensin II receptor
Ligand
BDBM50042251
Substrate
n/a
Meas. Tech.
ChEMBL_2129826 (CHEMBL4839255)
IC50
155±n/a nM
Citation
 Hernandez-Olmos, V; Heering, J; Bischoff-Kont, I; Kaps, A; Rajkumar, R; Liu, T; Fürst, R; Steinhilber, D; Proschak, E Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening. ACS Med Chem Lett 12:1261-1266 (2021) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50042251
Synonyms:
4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.5]dec-1-en-3-ylmethyl)-biphenyl-2-carboxylic acid | CHEMBL116170
Type:
Small organic molecule
Emp. Form.:
C26H30N2O3
Mol. Mass.:
418.528
SMILES:
CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1C(O)=O |t:4|
Structure:
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