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Found 42 with Last Name = 'bischoff-kont' and Initial = 'i'
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577226(CHEMBL4872989)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577227(CHEMBL4856425)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577229(CHEMBL4877651)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042251(4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.5]dec-1-en-3-y...)
Affinity DataIC50:  155nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042234(4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-y...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577228(CHEMBL4859498)
Affinity DataIC50:  390nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577231(CHEMBL4868159)
Affinity DataIC50:  1.01E+3nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042250(4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-ylmeth...)
Affinity DataIC50:  7.75E+3nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042236(4'-(2-Benzyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataIC50:  8.65E+3nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042263(4'-(4-Oxo-2-phenyl-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577230(CHEMBL4854916)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50130262(2,3,4,9-Tetrahydro-1H-beta-carboline | CHEMBL26923...)
Affinity DataEC50:  7.40E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50404775(CHEMBL31888)
Affinity DataEC50:  1.94E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580566(CHEMBL3304960)
Affinity DataEC50:  6.70E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50067133(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM60973((2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-...)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
Affinity DataEC50:  7.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580567(CHEMBL5070124)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580568(CHEMBL5088115)
Affinity DataEC50:  8.30E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580569(CHEMBL5083628)
Affinity DataEC50:  5.20E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50061966(CHEMBL139737 | Isopropyl-[3-(naphthalen-1-yloxy)-p...)
Affinity DataEC50:  5.00E+4nMAssay Description:Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as dec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50130262(2,3,4,9-Tetrahydro-1H-beta-carboline | CHEMBL26923...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50404775(CHEMBL31888)
Affinity DataEC50:  4.30E+4nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50580566(CHEMBL3304960)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Affinity DataEC50:  3.70E+4nMAssay Description:Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577230(CHEMBL4854916)
Affinity DataEC50:  7.50E+3nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577229(CHEMBL4877651)
Affinity DataEC50:  8.14E+3nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577228(CHEMBL4859498)
Affinity DataEC50:  6.39E+3nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042250(4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-ylmeth...)
Affinity DataEC50:  2.42E+4nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577227(CHEMBL4856425)
Affinity DataEC50:  550nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50577226(CHEMBL4872989)
Affinity DataEC50:  68nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042251(4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.5]dec-1-en-3-y...)
Affinity DataEC50:  860nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042236(4'-(2-Benzyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataEC50:  6.58E+3nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042234(4'-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-y...)
Affinity DataEC50:  1.49E+3nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50049186((S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group E member 1(Homo sapiens)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Affinity DataKd:  500nMAssay Description:Binding affinity to TLX LBD expressed in His6-tagged Escherichia coli Rosetta assessed as binding constant measured after 300 sec at 200 mM by isothe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataEC50:  410nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Fraunhofer Institute For Translational Medicine And Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50240609(2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed