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Target
NAD-dependent histone deacetylase SIR2
Ligand
BDBM50146070
Substrate
n/a
Meas. Tech.
ChEBML_202251
IC50
122000±n/a nM
Citation
 Posakony, J; Hirao, M; Stevens, S; Simon, JA; Bedalov, A Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem 47:2635-44 (2004) [PubMed]  Article 
Target
Name:
NAD-dependent histone deacetylase SIR2
Synonyms:
MAR1 | SIR2 | SIR2_YEAST
Type:
PROTEIN
Mol. Mass.:
63277.80
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_942450
Residue:
562
Sequence:
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
  
Inhibitor
Name:
BDBM50146070
Synonyms:
1,2-benzodihydropyrone | 2-chromanone | 2-hydroxydihydrocinnamic acid lactone | 3,4-dihydro-2H-1-benzopyran-2-one | 3,4-dihydro-2H-chromen-2-one | 3,4-dihydrocoumarin | CHEMBL89306 | chroman-2-one | hydrocoumarin | melilotic acid lactone | melilotic lactone | melilotin | melilotol | o-hydroxydihydrocinnamic acid lactone | o-hydroxyhydrocinnamic acid delta-lactone | oxochroman
Type:
Small organic molecule
Emp. Form.:
C9H8O2
Mol. Mass.:
148.1586
SMILES:
O=C1CCc2ccccc2O1
Structure:
Search PDB for entries with ligand similarity: