Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50147196
Substrate
n/a
Meas. Tech.
ChEMBL_158997 (CHEMBL763924)
IC50
193000±n/a nM
Citation
 Yehia, NA; Antuch, W; Beck, B; Hess, S; Schauer-Vukasinovic, V; Almstetter, M; Furer, P; Herdtweck, E; Dömling, A Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. Bioorg Med Chem Lett 14:3121-5 (2004) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50147196
Synonyms:
CHEMBL321798 | {4-Hydroxy-2-oxo-5-phenethyl-5-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-2,5-dihydro-furan-3-yl}-methyl-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C24H32N2O7
Mol. Mass.:
460.5201
SMILES:
CN(C1C(=O)OC(CCc2ccccc2)(C(=O)NCC2CCCO2)C1=O)C(=O)OC(C)(C)C
Structure:
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