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Found 55 with Last Name = 'almstetter' and Initial = 'm'
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149365(US8962860, 9)
Affinity DataKi:  3.24nM ΔG°:  -49.3kJ/mole IC50:  3.08nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149363(US8962860, 6)
Affinity DataKi:  3.80nM ΔG°:  -48.9kJ/mole IC50:  234nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149366(US8962860, 11)
Affinity DataKi:  4.13nM ΔG°:  -48.7kJ/mole IC50:  48nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149358(US8962860, 1)
Affinity DataKi:  6.07nM ΔG°:  -47.7kJ/mole IC50:  69.7nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149375(US8962860, 42)
Affinity DataKi:  6.49nM ΔG°:  -47.5kJ/mole IC50:  24nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149371(US8962860, 16)
Affinity DataKi:  13.6nM ΔG°:  -45.7kJ/mole IC50:  128nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149376(US8962860, 43)
Affinity DataKi:  17.7nM ΔG°:  -45.0kJ/mole IC50:  326nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149369(US8962860, 14)
Affinity DataKi:  21.7nM ΔG°:  -44.5kJ/mole IC50:  173nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149362(US8962860, 5)
Affinity DataKi:  34.8nM ΔG°:  -43.3kJ/mole IC50:  182nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149367(US8962860, 12)
Affinity DataKi:  36nM ΔG°:  -43.2kJ/mole IC50:  523nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149359(US8962860, 2)
Affinity DataKi:  41.3nM ΔG°:  -42.9kJ/mole IC50:  741nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149368(US8962860, 13)
Affinity DataKi:  42.8nM ΔG°:  -42.8kJ/mole IC50:  298nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149373(US8962860, 40)
Affinity DataKi:  45.9nM ΔG°:  -42.6kJ/mole IC50:  256nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149360(US8962860, 3)
Affinity DataKi:  48nM ΔG°:  -42.5kJ/mole IC50:  34.9nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149361(US8962860, 4)
Affinity DataKi:  51.6nM ΔG°:  -42.3kJ/mole IC50:  560nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149370(US8962860, 15)
Affinity DataKi:  58.5nM ΔG°:  -42.0kJ/mole IC50:  540nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149364(US8962860, 7)
Affinity DataKi:  65.5nM ΔG°:  -41.7kJ/mole IC50:  430nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149374(US8962860, 41)
Affinity DataKi:  85.3nM ΔG°:  -41.0kJ/mole IC50:  485nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM149372(US8962860, 32)
Affinity DataKi:  159nM ΔG°:  -39.5kJ/mole IC50:  821nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147191(4-(1,5-Dimethyl-hex-4-enyl)-3-hydroxy-5-oxo-2-phen...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50404246(CHEMBL2111673)
Affinity DataIC50:  1.20E+3nMAssay Description:Evaluated for inhibition of Protease after after resynthesis and purificationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147191(4-(1,5-Dimethyl-hex-4-enyl)-3-hydroxy-5-oxo-2-phen...)
Affinity DataIC50:  1.30E+3nMAssay Description:Evaluated for inhibition of Protease after CLND/MS correction from the crude mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147191(4-(1,5-Dimethyl-hex-4-enyl)-3-hydroxy-5-oxo-2-phen...)
Affinity DataIC50:  1.30E+3nMAssay Description:Evaluated for inhibition of Protease after after resynthesis and purificationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147193(3-Hydroxy-5-oxo-2-phenethyl-4-(1-phenyl-ethyl)-2,5...)
Affinity DataIC50:  2.00E+3nMAssay Description:Evaluated for inhibition of Protease after CLND/MS correction from the crude mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147197(3-Hydroxy-5-oxo-2,4-diphenethyl-2,5-dihydro-furan-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147193(3-Hydroxy-5-oxo-2-phenethyl-4-(1-phenyl-ethyl)-2,5...)
Affinity DataIC50:  4.00E+3nMAssay Description:Evaluated for inhibition of Protease after CLND/MS correction from the crude mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147193(3-Hydroxy-5-oxo-2-phenethyl-4-(1-phenyl-ethyl)-2,5...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50404246(CHEMBL2111673)
Affinity DataIC50:  4.60E+3nMAssay Description:Evaluated for inhibition of Protease from the crude plate mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50404246(CHEMBL2111673)
Affinity DataIC50:  4.60E+3nMAssay Description:Evaluated for inhibition of Protease after CLND/MS correction from the crude mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50404246(CHEMBL2111673)
Affinity DataIC50:  5.00E+3nMAssay Description:Evaluated for inhibition of Protease after after resynthesis and purificationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147193(3-Hydroxy-5-oxo-2-phenethyl-4-(1-phenyl-ethyl)-2,5...)
Affinity DataIC50:  6.00E+3nMAssay Description:Evaluated for inhibition of Protease from the crude plate mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Staphylococcus aureus)
Morphochem

LigandPNGBDBM17869((3S)-3-amino-1-(cyclopropylamino)heptane-2,2-diol ...)
Affinity DataIC50:  7.00E+3nMpH: 7.5 T: 2°CAssay Description:The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147195(4-Benzyl-3-hydroxy-5-oxo-2-phenethyl-2,5-dihydro-f...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147191(4-(1,5-Dimethyl-hex-4-enyl)-3-hydroxy-5-oxo-2-phen...)
Affinity DataIC50:  1.50E+4nMAssay Description:Evaluated for inhibition of Protease from the crude plate mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Staphylococcus aureus)
Morphochem

LigandPNGBDBM17868((2S)-2-amino-4-(methylsulfanyl)-1-(pyridin-2-yl)bu...)
Affinity DataIC50:  1.60E+4nMpH: 7.5 T: 2°CAssay Description:The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147209(4-(4-tert-Butyl-phenyl)-3-hydroxy-5-oxo-2-phenethy...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Staphylococcus aureus)
Morphochem

LigandPNGBDBM17867((2S)-2-amino-4-(methylsulfanyl)-1-(1,3-thiazol-2-y...)
Affinity DataIC50:  1.90E+4nMpH: 7.5 T: 2°CAssay Description:The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147201(4-Biphenyl-4-yl-3-hydroxy-5-oxo-2-phenethyl-2,5-di...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147203(3-Hydroxy-2-isopropyl-5-oxo-4-(1-phenyl-ethyl)-2,5...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147202((5-tert-Butylcarbamoyl-4-hydroxy-2-oxo-5-phenethyl...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147200(3-Hydroxy-2-methyl-5-oxo-4-phenethyl-2,5-dihydro-f...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50404246(CHEMBL2111673)
Affinity DataIC50:  8.40E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50404246(CHEMBL2111673)
Affinity DataIC50:  8.40E+4nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147190(3-Hydroxy-2-methyl-5-oxo-4-phenethyl-2,5-dihydro-f...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147198(3-Hydroxy-2-methyl-5-oxo-4-(1-phenyl-ethyl)-2,5-di...)
Affinity DataIC50:  1.05E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147204(3-Hydroxy-4-(1H-indol-3-yl)-5-oxo-2-phenethyl-2,5-...)
Affinity DataIC50:  1.07E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147194(4-(1,5-Dimethyl-hex-4-enyl)-3-hydroxy-2-methyl-5-o...)
Affinity DataIC50:  1.51E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147196(CHEMBL321798 | {4-Hydroxy-2-oxo-5-phenethyl-5-[(te...)
Affinity DataIC50:  1.93E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147208(3-Hydroxy-2-methyl-5-oxo-4-(1-phenyl-ethyl)-2,5-di...)
Affinity DataIC50:  2.24E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Morphochem

Curated by ChEMBL
LigandPNGBDBM50147199(3-Hydroxy-2-methyl-5-oxo-4-(1-phenyl-ethyl)-2,5-di...)
Affinity DataIC50:  2.44E+5nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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