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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50147193
Substrate
n/a
Meas. Tech.
ChEMBL_158989 (CHEMBL763755)
IC50
4100±n/a nM
Citation
 Yehia, NA; Antuch, W; Beck, B; Hess, S; Schauer-Vukasinovic, V; Almstetter, M; Furer, P; Herdtweck, E; Dömling, A Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. Bioorg Med Chem Lett 14:3121-5 (2004) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50147193
Synonyms:
3-Hydroxy-5-oxo-2-phenethyl-4-(1-phenyl-ethyl)-2,5-dihydro-furan-2-carboxylic acid tert-butylamide | CHEMBL324640
Type:
Small organic molecule
Emp. Form.:
C25H29NO4
Mol. Mass.:
407.5021
SMILES:
CC(C1C(=O)OC(CCc2ccccc2)(C(=O)NC(C)(C)C)C1=O)c1ccccc1
Structure:
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