Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50148119
Substrate
n/a
Meas. Tech.
ChEMBL_86908 (CHEMBL698418)
Ki
108±n/a nM
Citation
 Pelloux-Léon, N; Fkyerat, A; Piripitsi, A; Tertiuk, W; Schunack, W; Stark, H; Garbarg, M; Ligneau, X; Arrang, JM; Schwartz, JC; Ganellin, CR Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. J Med Chem 47:3264-74 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50148119
Synonyms:
3-[3-(1H-Imidazol-4-yl)-propoxy]-benzonitrile | CHEMBL110582
Type:
Small organic molecule
Emp. Form.:
C13H13N3O
Mol. Mass.:
227.2618
SMILES:
N#Cc1cccc(OCCCc2cnc[nH]2)c1
Structure:
Search PDB for entries with ligand similarity: