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Target
Histamine H3 receptor
Ligand
BDBM50409931
Substrate
n/a
Meas. Tech.
ChEMBL_86908 (CHEMBL698418)
Ki
20±n/a nM
Citation
 Pelloux-Léon, N; Fkyerat, A; Piripitsi, A; Tertiuk, W; Schunack, W; Stark, H; Garbarg, M; Ligneau, X; Arrang, JM; Schwartz, JC; Ganellin, CR Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. J Med Chem 47:3264-74 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50409931
Synonyms:
CHEMBL2112499
Type:
Small organic molecule
Emp. Form.:
C14H16N2O2
Mol. Mass.:
244.289
SMILES:
CC(=O)c1cccc(OCCCc2cnc[nH]2)c1
Structure:
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