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Target
Nuclear receptor subfamily 2 group E member 1
Ligand
BDBM14777
Substrate
n/a
Meas. Tech.
ChEMBL_2148634 (CHEMBL5033032)
EC50
5000±n/a nM
Citation
 Faudone, G; Bischoff-Kont, I; Rachor, L; Willems, S; Zhubi, R; Kaiser, A; Chaikuad, A; Knapp, S; Fürst, R; Heering, J; Merk, D Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. J Med Chem 64:8727-8738 (2021) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 2 group E member 1
Synonyms:
NR2E1 | NR2E1_HUMAN | Nuclear receptor TLX | Protein tailless homolog | TLX | Tll | hTll
Type:
PROTEIN
Mol. Mass.:
42606.25
Organism:
Homo sapiens
Description:
ChEMBL_104473
Residue:
385
Sequence:
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
  
Inhibitor
Name:
BDBM14777
Synonyms:
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione | CHEMBL779 | Cialis | GF 196960 | Tadalafil
Type:
Small organic molecule
Emp. Form.:
C22H19N3O4
Mol. Mass.:
389.404
SMILES:
[H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r|
Structure:
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