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Target
Nuclear receptor subfamily 2 group E member 1
Ligand
BDBM25761
Substrate
n/a
Meas. Tech.
ChEMBL_2148637 (CHEMBL756433)
EC50
32000±n/a nM
Citation
 Faudone, G; Bischoff-Kont, I; Rachor, L; Willems, S; Zhubi, R; Kaiser, A; Chaikuad, A; Knapp, S; Fürst, R; Heering, J; Merk, D Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. J Med Chem 64:8727-8738 (2021) [PubMed]  Article  BDB Entry
Target
Name:
Nuclear receptor subfamily 2 group E member 1
Synonyms:
NR2E1 | Nuclear receptor TLX | Protein tailless homolog | TLX | Tll | hTll
Type:
PROTEIN
Mol. Mass.:
42606.25
Organism:
Homo sapiens
Description:
ChEMBL_104473
Residue:
385
Sequence:
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
  
Inhibitor
Name:
BDBM25761
Synonyms:
Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-) | PROPRANOLOL, d | PROPRANOLOL, l- | PROPRANOLOL,(+) | PROPRANOLOL,(-) | Propanolol | Propanolol,(+/-) | Propranolol | [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
Type:
Small organic molecule
Emp. Form.:
C16H21NO2
Mol. Mass.:
259.3434
SMILES:
CC(C)NCC(O)COc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: