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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50149724
Substrate
n/a
Meas. Tech.
ChEMBL_302559 (CHEMBL839522)
Ki
790±n/a nM
Citation
 Chackalamannil, S; Doller, D; McQuade, R; Ruperto, V Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations. Bioorg Med Chem Lett 14:3967-70 (2004) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50149724
Synonyms:
(S)-6,6,7-Trimethyl-2-((3S,3aR,4R,4aR,9aS)-3-methyl-1-oxo-1,3,3a,4,4a,5,6,7,8,9a-decahydro-naphtho[2,3-c]furan-4-yl)-hexahydro-pyrrolo[1,2-b]isoxazol-7-ium; iodide | CHEMBL363895
Type:
Small organic molecule
Emp. Form.:
C22H34NO3
Mol. Mass.:
360.5097
SMILES:
C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12 |t:6|
Structure:
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