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Target
Glucocorticoid receptor
Ligand
BDBM50150317
Substrate
n/a
Meas. Tech.
ChEMBL_305896 (CHEMBL874547)
IC50
13±n/a nM
Citation
 Link, JT; Sorensen, BK; Patel, J; Arendsen, D; Li, G; Swanson, S; Nguyen, B; Emery, M; Grynfarb, M; Goos-Nilsson, A Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators. Bioorg Med Chem Lett 14:4169-72 (2004) [PubMed]  Article 
Target
Name:
Glucocorticoid receptor
Synonyms:
GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:
Enzyme
Mol. Mass.:
85656.87
Organism:
Homo sapiens (Human)
Description:
P04150
Residue:
777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
  
Inhibitor
Name:
BDBM50150317
Synonyms:
CHEMBL182842 | N-{3-[(4-Benzoyl-benzyl)-benzyl-amino]-2-methyl-phenyl}-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C29H28N2O3S
Mol. Mass.:
484.609
SMILES:
Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccccc1)Cc1ccc(cc1)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: