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Target
M-phase inducer phosphatase 1
Ligand
BDBM50150613
Substrate
n/a
Meas. Tech.
ChEMBL_305898 (CHEMBL832081)
IC50
700±n/a nM
Citation
 Shimazawa, R; Gochomori, M; Shirai, R Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue. Bioorg Med Chem Lett 14:4339-42 (2004) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50150613
Synonyms:
CHEMBL179992 | CHEMBL182645 | [(1R,4S,7aR)-1-(1,5-dimethylhexyl)-4,7a-dimethyloctahydro-1H-inden-4-yl]methyl dihydrogen phosphate
Type:
Small organic molecule
Emp. Form.:
C20H39O4P
Mol. Mass.:
374.495
SMILES:
CC(C)CCC[C@@H](C)[C@H]1CCC2[C@]1(C)CCCC2(C)COP(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: