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Target
Stimulator of interferon genes protein
Ligand
BDBM50582523
Substrate
n/a
Meas. Tech.
ChEMBL_2154864 (CHEMBL5039524)
EC50
280±n/a nM
Citation
 Vyskocil, S; Cardin, D; Ciavarri, J; Conlon, J; Cullis, C; England, D; Gershman, R; Gigstad, K; Gipson, K; Gould, A; Greenspan, P; Griffin, R; Gulavita, N; Harrison, S; Hu, Z; Hu, Y; Hata, A; Huang, J; Huang, SC; Janowick, D; Jones, M; Kolev, V; Langston, SP; Lee, HM; Li, G; Lok, D; Ma, L; Mai, D; Malley, J; Matsuda, A; Mizutani, H; Mizutani, M; Molchanova, N; Nunes, E; Pusalkar, S; Renou, C; Rowland, S; Sato, Y; Shaw, M; Shen, L; Shi, Z; Skene, R; Soucy, F; Stroud, S; Xu, H; Xu, T; Abu-Yousif, AO; Zhang, J Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J Med Chem 64:6902-6923 (2021) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Endoplasmic reticulum interferon stimulator | Eris | MMITA | Mediator of IRF3 activation | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein | Sting | Sting1 | Synonyms=Eris | Tmem173 | Transmembrane protein 173 | mSTING
Type:
PROTEIN
Mol. Mass.:
42834.49
Organism:
Mus musculus
Description:
ChEMBL_119061
Residue:
378
Sequence:
MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTLKYLALHLASHELGLLLKNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLSSYFYFLQNTADIYLSWMFGLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEPRLLISGMDQPLPLRTDLI
  
Inhibitor
Name:
BDBM50582523
Synonyms:
CHEMBL5086820
Type:
Small organic molecule
Emp. Form.:
C20H25N7O10P2S2
Mol. Mass.:
649.531
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2CO[P@](S)(=O)O[C@H]3C[C@@H](C[C@@H]3CO[P@](S)(=O)O[C@@H]1[C@@H]2O)Oc1ccncn1 |r|
Structure:
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