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Target
Melanocortin receptor 3
Ligand
BDBM50151509
Substrate
n/a
Meas. Tech.
ChEMBL_302996 (CHEMBL830235)
Ki
6500±n/a nM
Citation
 Mutulis, F; Yahorava, S; Mutule, I; Yahorau, A; Liepinsh, E; Kopantshuk, S; Veiksina, S; Tars, K; Belyakov, S; Mishnev, A; Rinken, A; Wikberg, JE New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of"THIQ". J Med Chem 47:4613-26 (2004) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50151509
Synonyms:
1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-((1S,2S)-2-[1,2,4]triazol-1-yl-cyclohexyl)-piperazin-1-yl]-ethyl}-amide | CHEMBL362670
Type:
Small organic molecule
Emp. Form.:
C31H38ClN7O2
Mol. Mass.:
576.132
SMILES:
Clc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCN(CC2)[C@H]2CCCC[C@@H]2n2cncn2)cc1
Structure:
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