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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50152047
Substrate
n/a
Meas. Tech.
ChEMBL_306747 (CHEMBL830892)
IC50
2990±n/a nM
Citation
 Hartz, RA; Nanda, KK; Ingalls, CL; Ahuja, VT; Molski, TF; Zhang, G; Wong, H; Peng, Y; Kelley, M; Lodge, NJ; Zaczek, R; Gilligan, PJ; Trainor, GL Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6h-purin-6-one and 3,7-dihydro-1h-purine-2,6-dione derivatives as corticotropin-releasing factor(1) receptor antagonists. J Med Chem 47:4741-54 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47870.75
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortex homogenate.
Residue:
415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50152047
Synonyms:
3-(2,4-Dichloro-phenyl)-8-ethyl-7-(1-ethyl-propyl)-1-methyl-3,7-dihydro-purine-2,6-dione | CHEMBL182591
Type:
Small organic molecule
Emp. Form.:
C19H22Cl2N4O2
Mol. Mass.:
409.31
SMILES:
CCC(CC)n1c(CC)nc2n(-c3ccc(Cl)cc3Cl)c(=O)n(C)c(=O)c12 |(-1.38,5.87,;-.9,4.4,;-1.93,3.26,;-3.44,3.58,;-3.91,5.05,;-1.46,1.79,;-2.37,.55,;-3.91,.55,;-4.68,1.88,;-1.46,-.7,;,-.22,;1.34,-1,;1.34,-2.52,;2.66,-3.29,;2.66,-4.81,;1.34,-5.6,;1.34,-7.14,;,-4.83,;,-3.29,;-1.33,-2.52,;2.66,-.22,;3.99,-1,;2.66,1.32,;3.99,2.1,;1.34,2.09,;1.31,3.63,;,1.31,)|
Structure:
Search PDB for entries with ligand similarity: