Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50152524
Substrate
n/a
Meas. Tech.
ChEMBL_306183 (CHEMBL830977)
IC50
>500±n/a nM
Citation
Barrett, DG; Catalano, JG; Deaton, DN; Hassell, AM; Long, ST; Miller, AB; Miller, LR; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions. Bioorg Med Chem Lett 14:4897-902 (2004) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Inhibitor
Name:
BDBM50152524
Synonyms:
(S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate | CHEMBL185097 | [(S)-1-(2H-Pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester | [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE
Type:
Small organic molecule
Emp. Form.:
C23H29FN4O4
Mol. Mass.:
444.4992
SMILES:
CCCC[C@H](NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)C(=O)C(=O)Nc1ccn[nH]1