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Target
Cathepsin S
Ligand
BDBM50152984
Substrate
n/a
Meas. Tech.
ChEMBL_305367 (CHEMBL832883)
IC50
5±n/a nM
Citation
 Thurmond, RL; Beavers, MP; Cai, H; Meduna, SP; Gustin, DJ; Sun, S; Almond, HJ; Karlsson, L; Edwards, JP Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S. J Med Chem 47:4799-801 (2004) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50152984
Synonyms:
1-(4-Phenyl-piperazin-1-yl)-3-(3-phenyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl)-propan-2-ol | CHEMBL363669
Type:
Small organic molecule
Emp. Form.:
C25H31N5O
Mol. Mass.:
417.5465
SMILES:
OC(CN1CCN(CC1)c1ccccc1)Cn1nc(c2CNCCc12)-c1ccccc1
Structure:
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