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Target
CD63 antigen
Ligand
BDBM324284
Substrate
n/a
Meas. Tech.
ChEMBL_2158550 (CHEMBL5043300)
IC50
82±n/a nM
Citation
 Hopkins, BT; Bame, E; Bajrami, B; Black, C; Bohnert, T; Boiselle, C; Burdette, D; Burns, JC; Delva, L; Donaldson, D; Grater, R; Gu, C; Hoemberger, M; Johnson, J; Kapadnis, S; King, K; Lulla, M; Ma, B; Marx, I; Magee, T; Meissner, R; Metrick, CM; Mingueneau, M; Murugan, P; Otipoby, KL; Polack, E; Poreci, U; Prince, R; Roach, AM; Rowbottom, C; Santoro, JC; Schroeder, P; Tang, H; Tien, E; Zhang, F; Lyssikatos, J Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis. J Med Chem 65:1206-1224 (2022) [PubMed]  Article 
Target
Name:
CD63 antigen
Synonyms:
CD63 | CD63_HUMAN | CD_antigen: CD63 | CD_antigen=CD63 | Granulophysin | LAMP-3 | Limp1 | Lysosomal-associated membrane protein 3 | Lysosome integral membrane protein 1 | MLA1 | Melanoma-associated antigen ME491 | OMA81H | Ocular melanoma-associated antigen | TSPAN30 | Tetraspanin-30 | Tspan-30
Type:
n/a
Mol. Mass.:
25640.41
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
238
Sequence:
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM
  
Inhibitor
Name:
BDBM324284
Synonyms:
(R)-1-(tert-butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide | US10189829, Compound 27 | US10227341, Compound 27 | US10961237, Compound 27 | US11858926, Compound 27
Type:
Small organic molecule
Emp. Form.:
C28H34N10O2
Mol. Mass.:
542.6354
SMILES:
Cn1cc(Nc2nccc(n2)-c2ccc3[C@@H](CCN(Cc3c2)C2COC2)NC(=O)c2cn(nn2)C(C)(C)C)cn1 |r|
Structure:
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