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Target
Mu-type opioid receptor
Ligand
BDBM50583967
Substrate
n/a
Meas. Tech.
ChEMBL_2158626 (CHEMBL5043376)
EC50
0.070000±n/a nM
Citation
 Yang, Y; Wang, Y; Zuo, A; Li, C; Wang, W; Jiang, W; Zhang, X; Che, X; Zhang, Y; Wu, W; Cen, X; Wang, H; Tian, J Synthesis, biological, and structural explorations of a series of ?-opioid receptor (MOR) agonists with high G protein signaling bias. Eur J Med Chem 228:0 (2022) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50583967
Synonyms:
CHEMBL5074742
Type:
Small organic molecule
Emp. Form.:
C24H30FNO2S
Mol. Mass.:
415.564
SMILES:
Fc1ccc(cc1)[C@]1(CCNCc2scc3CCCc23)CCOC2(CCOC2)C1 |r|
Structure:
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