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Target
Delta-type opioid receptor
Ligand
BDBM50493818
Substrate
n/a
Meas. Tech.
ChEMBL_2158649 (CHEMBL5043399)
EC50
>10000±n/a nM
Citation
 Yang, Y; Wang, Y; Zuo, A; Li, C; Wang, W; Jiang, W; Zhang, X; Che, X; Zhang, Y; Wu, W; Cen, X; Wang, H; Tian, J Synthesis, biological, and structural explorations of a series of ?-opioid receptor (MOR) agonists with high G protein signaling bias. Eur J Med Chem 228:0 (2022) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50493818
Synonyms:
Oliceridine | TRV-130 | US11124523, Comparative Compound 1 | US11484525, Compound TRV-130
Type:
Small organic molecule
Emp. Form.:
C22H30N2O2S
Mol. Mass.:
386.551
SMILES:
COc1ccsc1CNCC[C@]1(CCOC2(CCCC2)C1)c1ccccn1 |r|
Structure:
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