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Target
DCN1-like protein 5
Ligand
BDBM50584167
Substrate
n/a
Meas. Tech.
ChEMBL_2159071 (CHEMBL5043821)
Ki
28940±n/a nM
Citation
 He, ZX; An, Q; Wei, B; Zhou, WJ; Wei, BF; Gong, YP; Zhang, X; Gao, G; Dong, GJ; Huo, JL; Zhang, XH; Yang, FF; Liu, HM; Ma, LY; Zhao, W Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem 65:163-190 (2022) [PubMed]  Article 
Target
Name:
DCN1-like protein 5
Synonyms:
DCN1-like protein 5 | DCNL5 | DCNL5_HUMAN | DCUN1 domain-containing protein 5 | DCUN1D5 | Defective in cullin neddylation protein 1-like protein 5 | SCCRO5 | Squamous cell carcinoma-related oncogene 5 | Synonyms=SCCRO5
Type:
PROTEIN
Mol. Mass.:
27505.07
Organism:
Homo sapiens
Description:
ChEMBL_118182
Residue:
237
Sequence:
MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAGPDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS
  
Inhibitor
Name:
BDBM50584167
Synonyms:
CHEMBL5085822
Type:
Small organic molecule
Emp. Form.:
C23H20ClN7O3S2
Mol. Mass.:
542.033
SMILES:
COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(Cl)cc2)nc(Sc2nnnn2C)c1C#N
Structure:
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