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Target
Protein cereblon
Ligand
BDBM50586184
Substrate
n/a
Meas. Tech.
ChEMBL_2165247 (CHEMBL5050108)
IC50
0.450000±n/a nM
Citation
 Alcock, LJ; Chang, Y; Jarusiewicz, JA; Actis, M; Nithianantham, S; Mayasundari, A; Min, J; Maxwell, D; Hunt, J; Smart, B; Yang, JJ; Nishiguchi, G; Fischer, M; Mullighan, CG; Rankovic, Z Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. ACS Med Chem Lett 13:475-482 (2022) [PubMed]  Article 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM50586184
Synonyms:
CHEMBL5078429
Type:
Small organic molecule
Emp. Form.:
C40H44N12O5S
Mol. Mass.:
804.92
SMILES:
CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1nc(Nc2ccc(cc2)C(=O)NCCN2CCN(CC2)c2ccc(cc2)C2CCC(=O)NC2=O)nc2[nH]ccc12
Structure:
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