Reaction Details Report a problem with these data
Target
Lactoylglutathione lyase
Ligand
BDBM50160866
Substrate
n/a
Meas. Tech.
ChEMBL_302327 (CHEMBL828914)
Ki
183000±n/a nM
Citation
 Kamiya, D; Uchihata, Y; Ichikawa, E; Kato, K; Umezawa, K Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I. Bioorg Med Chem Lett 15:1111-4 (2005) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50160866
Synonyms:
CHEMBL360309 | [2-(4-Amino-5,5-dihydroxy-pentanoylamino)-3-(3,4,5-trihydroxy-6-oxo-cyclohex-1-enylmethylsulfanyl)-propionylamino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C17H25N3O10S
Mol. Mass.:
463.46
SMILES:
NC(CCC(=O)NC(CSCC1C[C@@H](O)[C@@H](O)C(=O)C1=O)C(=O)NCC(O)=O)C(O)=O
Structure:
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