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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50589703
Substrate
n/a
Meas. Tech.
ChEMBL_2194160 (CHEMBL5106520)
IC50
0.400000±n/a nM
Citation
 Foot, JS; Buson, A; Deodhar, M; Findlay, AD; Robertson, AD; Turner, CI; Yow, T; Zhou, W; Jarolimek, W Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease. Bioorg Med Chem Lett 74:0 (2022) [PubMed] 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_MOUSE | Amine oxidase [flavin-containing] B | MAO-B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase type B
Type:
PROTEIN
Mol. Mass.:
58568.67
Organism:
Mus musculus
Description:
ChEMBL_605809
Residue:
520
Sequence:
MSNKSDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDNNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTKSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVIVKTLNHEIYEAKYVISAIPPALGMKIHYSPPLPMLRNQLISRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGTYAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESLDVPARPITSTFLERHLPSVPGLLKLFGLTTILSATALGFLAHKRGLFVHF
  
Inhibitor
Name:
BDBM50589703
Synonyms:
CHEMBL5196906
Type:
Small organic molecule
Emp. Form.:
C11H13ClFNO
Mol. Mass.:
229.678
SMILES:
Cl.NC\C(=C/F)[C@H]1Cc2ccccc2O1 |r|
Structure:
Search PDB for entries with ligand similarity: