Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50161582
Substrate
n/a
Meas. Tech.
ChEMBL_306671 (CHEMBL832272)
IC50
46±n/a nM
Citation
 Plummer, CW; Finke, PE; Mills, SG; Wang, J; Tong, X; Doss, GA; Fong, TM; Lao, JZ; Schaeffer, MT; Chen, J; Shen, CP; Stribling, DS; Shearman, LP; Strack, AM; Van der Ploeg, LH Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists. Bioorg Med Chem Lett 15:1441-6 (2005) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50161582
Synonyms:
4-(4-Chloro-phenyl)-5-(2,4-dichloro-phenyl)-1-methyl-1H-imidazole-2-carboxylic acid cyclohexylamide | CHEMBL368441
Type:
Small organic molecule
Emp. Form.:
C23H22Cl3N3O
Mol. Mass.:
462.799
SMILES:
Cn1c(nc(c1-c1ccc(Cl)cc1Cl)-c1ccc(Cl)cc1)C(=O)NC1CCCCC1 |(-3.33,1.68,;-2.14,1.1,;-.62,2.17,;.64,1.3,;.21,-.17,;-1.34,-.22,;-2.09,-1.57,;-1.28,-2.88,;-2.03,-4.24,;-3.58,-4.25,;-4.33,-5.62,;-4.38,-2.95,;-3.61,-1.59,;-4.41,-.29,;1.01,-1.52,;2.55,-1.45,;3.34,-2.76,;2.61,-4.13,;3.41,-5.44,;1.06,-4.17,;.26,-2.83,;-.67,3.72,;-2.02,4.47,;.66,4.52,;2.01,3.82,;3.33,3.03,;4.66,3.79,;4.66,5.33,;3.32,6.1,;2.01,5.33,)|
Structure:
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