Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM50590345
Substrate
n/a
Meas. Tech.
ChEMBL_2196310 (CHEMBL5108826)
IC50
2.6±n/a nM
Citation
 Luo, Z; Liu, H; Yu, Y; Gropler, RJ; Klein, RS; Tu, Z Synthesis and evaluation of highly selective quinazoline-2,4-dione ligands for sphingosine-1-phosphate receptor 2. RSC Med Chem 13:202-207 (2022) [PubMed] 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM50590345
Synonyms:
CHEMBL5192525
Type:
Small organic molecule
Emp. Form.:
C26H23ClN4O7
Mol. Mass.:
538.936
SMILES:
COc1cc(OC)c(NC(=O)Cn2c3ccccc3c(=O)n(CC(=O)Nc3ccc(O)cc3)c2=O)cc1Cl
Structure:
Search PDB for entries with ligand similarity: