Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50162101
Substrate
n/a
Meas. Tech.
ChEMBL_306530 (CHEMBL829597)
IC50
37±n/a nM
Citation
 Harper, S; Pacini, B; Avolio, S; Di Filippo, M; Migliaccio, G; Laufer, R; De Francesco, R; Rowley, M; Narjes, F Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase. J Med Chem 48:1314-7 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50162101
Synonyms:
1-Benzyl-3-cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid | CHEMBL369320
Type:
Small organic molecule
Emp. Form.:
C28H27NO2
Mol. Mass.:
409.5195
SMILES:
OC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3)n(Cc3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: