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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50591386
Substrate
n/a
Meas. Tech.
ChEMBL_2200212 (CHEMBL5112728)
Kd
28000±n/a nM
Citation
 Suenkel, B; Valente, S; Zwergel, C; Weiss, S; Di Bello, E; Fioravanti, R; Aventaggiato, M; Amorim, JA; Garg, N; Kumar, S; Lombard, DB; Hu, T; Singh, PK; Tafani, M; Palmeira, CM; Sinclair, D; Mai, A; Steegborn, C Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5. J Med Chem 65:14015-14031 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50591386
Synonyms:
CHEMBL5171187
Type:
Small organic molecule
Emp. Form.:
C27H29NO8
Mol. Mass.:
495.5211
SMILES:
CCOC(=O)C1=CN(C=C(C1c1ccccc1)C(=O)OCC)C(=O)c1cc(OC)c(OC)c(OC)c1 |c:8,t:5|
Structure:
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