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maximum 50k data
Found 156 with Last Name = 'zwergel' and Initial = 'c'
LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataIC50:  1.80nMAssay Description:Dissociation constant against VEGF (vascular endothelial growth factor) was determined.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM50410563(CHEMBL5268403)
Affinity DataIC50:  4.5nMAssay Description:Dissociation constant against VEGF (vascular endothelial growth factor) was determined.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50540803(CHEMBL4633299)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC6 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM291687(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  5.90nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Escherichia coliMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50540804(CHEMBL4639495)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant HDAC6 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50087841(CHEMBL3426804)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant HDAC6 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant HDAC10 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50208827(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Affinity DataIC50:  55nMAssay Description:Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50208827(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Affinity DataIC50:  78nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087841(CHEMBL3426804)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251697(CHEMBL4093222)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for its ability to displace [3H]-cytisine binding from high-affinity Nicotinic acetylcholine receptor in rat brain (principall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant HDAC11 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50540803(CHEMBL4633299)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant HDAC8 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50448484(CHEMBL3126646)
Affinity DataIC50:  120nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant HDAC8 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant HDAC1 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251724(CHEMBL4066424)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM50410560(CHEMBL5283723)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human recombinant HDAC3 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50448487(CHEMBL2385821)
Affinity DataIC50:  370nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human recombinant HDAC5 using AMC-K(TFA)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251670(CHEMBL4085485)
Affinity DataIC50:  400nMAssay Description:Compound was evaluated for its ability to displace [3H]-cytisine binding from high-affinity Nicotinic acetylcholine receptor in rat brain (principall...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50540803(CHEMBL4633299)
Affinity DataIC50:  430nMAssay Description:Inhibition of human recombinant HDAC1 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50540803(CHEMBL4633299)
Affinity DataIC50:  450nMAssay Description:Inhibition of human recombinant HDAC3 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human recombinant HDAC4 using AMC-K(TFA)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50087845(CHEMBL3426803)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50087841(CHEMBL3426804)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant HDAC8 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50448489(CHEMBL3126651)
Affinity DataIC50:  650nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251672(CHEMBL4060132)
Affinity DataIC50:  690nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251671(CHEMBL4097725)
Affinity DataIC50:  770nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251688(CHEMBL4086414)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50540804(CHEMBL4639495)
Affinity DataIC50:  830nMAssay Description:Inhibition of human recombinant HDAC1 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  850nMAssay Description:Inhibition of human N-terminal 600 residues-deleted DNMT1 using poly(dI-dC) as substrate in presence of AdoMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM50259910(CHEMBL4097892)
Affinity DataIC50:  890nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Escherichia coliMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  920nMAssay Description:Inhibition of human recombinant HDAC2 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251687(CHEMBL4066643)
Affinity DataIC50:  980nMAssay Description:Compound was evaluated for its ability to displace [3H]-cytisine binding from high-affinity Nicotinic acetylcholine receptor in rat brain (principall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251723(CHEMBL4094178)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251724(CHEMBL4066424)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25A expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50540803(CHEMBL4633299)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of human recombinant HDAC2 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50087841(CHEMBL3426804)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251732(CHEMBL4075821)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50540804(CHEMBL4639495)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of human recombinant HDAC3 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251697(CHEMBL4093222)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25A expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeaeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50251671(CHEMBL4097725)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged CDC25A expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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