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Target
Cyclin-dependent kinase 4
Ligand
BDBM50164691
Substrate
n/a
Meas. Tech.
ChEMBL_304677 (CHEMBL827031)
IC50
57.0±n/a nM
Citation
 Verma, S; Nagarathnam, D; Shao, J; Zhang, L; Zhao, J; Wang, Y; Li, T; Mull, E; Enyedy, I; Wang, C; Zhu, Q; Altieri, M; Jordan, J; Dang, TT; Reddy, S Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 15:1973-7 (2005) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50164691
Synonyms:
CHEMBL372464 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(4-methoxy-phenyl)-5-trifluoromethyl-pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C19H15F3N6O
Mol. Mass.:
400.3572
SMILES:
COc1ccc(Nc2nc(Nc3ccc4nc[nH]c4c3)ncc2C(F)(F)F)cc1
Structure:
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