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Found 270 with Last Name = 'jordan' and Initial = 'j'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305342(4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.0...)
Affinity DataKi:  12nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305341(8-(3'-Fluorophenethyl)amino-4-oxapentacyclo[5.4.1....)
Affinity DataKi:  20nMAssay Description:Binding affinity to Alpha2C adrenoceptor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305341(8-(3'-Fluorophenethyl)amino-4-oxapentacyclo[5.4.1....)
Affinity DataKi:  20nMAssay Description:Binding affinity to Alpha2C adrenoceptor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305341(8-(3'-Fluorophenethyl)amino-4-oxapentacyclo[5.4.1....)
Affinity DataKi:  137nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305341(8-(3'-Fluorophenethyl)amino-4-oxapentacyclo[5.4.1....)
Affinity DataKi:  149nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305343(4-(3'-Fluorophenyl)methyl-4-azahexacyclo[5.4.1.02,...)
Affinity DataKi:  153nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305344(8-(3'-Fluorobenzyl)amino-4-oxapentacyclo[5.4.1.02,...)
Affinity DataKi:  2.28E+3nMAssay Description:Binding affinity to sigma 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305341(8-(3'-Fluorophenethyl)amino-4-oxapentacyclo[5.4.1....)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305343(4-(3'-Fluorophenyl)methyl-4-azahexacyclo[5.4.1.02,...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305344(8-(3'-Fluorobenzyl)amino-4-oxapentacyclo[5.4.1.02,...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305343(4-(3'-Fluorophenyl)methyl-4-azahexacyclo[5.4.1.02,...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Alpha2C adrenoceptor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305342(4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.0...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Alpha2C adrenoceptor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305341(8-(3'-Fluorophenethyl)amino-4-oxapentacyclo[5.4.1....)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50305342(4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.0...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164702(4-[4-(3H-Benzoimidazol-5-ylamino)-5-trifluoromethy...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50172100(CHEMBL3809870)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant BACE1 expressed in HEK293 cells using peptide sequence EVNLAAEF as substrate preincubated for 60 mins followed by sub...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164693(CHEMBL194721 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164726((3H-Benzoimidazol-5-yl)-(4-isobutoxy-5-trifluorome...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164724(CHEMBL193922 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50148732(17-ethynyl-17beta-hydroxyestr-4-en-3-one | 17alpha...)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164711(CHEMBL195423 | N*2*-(3H-Benzoimidazol-5-yl)-5-brom...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164725(CHEMBL193367 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164706((3H-Benzoimidazol-5-yl)-(4-o-tolyloxy-5-trifluorom...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164691(CHEMBL372464 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164705(CHEMBL372465 | N*4*-Benzo[1,3]dioxol-5-yl-N*2*-(3H...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50172104(CHEMBL3808441)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant BACE1 expressed in HEK293 cells using peptide sequence EVNLAAEF as substrate preincubated for 60 mins followed by sub...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164710(CHEMBL370728 | N*4*-(3H-Benzoimidazol-5-yl)-5-brom...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50190017((4R,5R)-4-(2-fluorophenyl)-5-((S)-hydroxy(5-phenyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant 17beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164695(CHEMBL193519 | N*2*,N*4*-Bis-(1H-benzoimidazol-5-y...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164696(CHEMBL195641 | N*4*-[4-(3H-Benzoimidazol-5-ylamino...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164704(CHEMBL364935 | N*4*-(3H-Benzoimidazol-5-yl)-N*2*-(...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164694(CHEMBL372503 | N*2*,N*4*-Bis-(1H-benzoimidazol-5-y...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50172106(CHEMBL3809897)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant BACE1 expressed in HEK293 cells using peptide sequence EVNLAAEF as substrate preincubated for 60 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164703(CHEMBL363138 | N*4*-(3H-Benzoimidazol-5-yl)-5-trif...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164727(CHEMBL444874 | N*4*-(3H-Benzoimidazol-5-yl)-N*2*-m...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50172100(CHEMBL3809870)
Affinity DataIC50:  16nMAssay Description:Inhibition of BACE1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  17nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048167((3,4-Dichloro-phenyl)-(3-phenyl-5,6-dihydro-4H-pyr...)
Affinity DataIC50:  18nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164712(CHEMBL372672 | N*4*-(3H-Benzoimidazol-5-yl)-N*2*-(...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048158((3,4-Dichloro-phenyl)-(4-methyl-3-phenyl-5,6-dihyd...)
Affinity DataIC50:  24nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164730((3H-Benzoimidazol-5-yl)-(4-isopropoxy-5-trifluorom...)
Affinity DataIC50:  25nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50172105(CHEMBL3808967)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant BACE1 expressed in HEK293 cells using peptide sequence EVNLAAEF as substrate preincubated for 60 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164693(CHEMBL194721 | N*2*-(3H-Benzoimidazol-5-yl)-N*4*-(...)
Affinity DataIC50:  29nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50190020(4-(5-((S)-hydroxy((2R,3R)-1-methyl-5-oxo-3-phenylp...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant 17beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50190010((4R,5R)-4-(2-fluorophenyl)-5-((S)-hydroxy(5-(pyrid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of estradiol to estrone conversion in MG63 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50190010((4R,5R)-4-(2-fluorophenyl)-5-((S)-hydroxy(5-(pyrid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant 17beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164717((3H-Benzoimidazol-5-yl)-[4-(4-fluoro-phenoxy)-5-tr...)
Affinity DataIC50:  32nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164713(CHEMBL370485 | N*2*-(3H-Benzoimidazol-5-yl)-5-brom...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50164708(CHEMBL194032 | N*2*-(3H-Benzoimidazol-5-yl)-5-brom...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048153((3-Bromo-4-fluoro-phenyl)-(3-phenyl-5,6-dihydro-4H...)
Affinity DataIC50:  38nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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