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Target
Mitogen-activated protein kinase 3
Ligand
BDBM50164704
Substrate
n/a
Meas. Tech.
ChEMBL_304950 (CHEMBL826978)
IC50
750±n/a nM
Citation
 Verma, S; Nagarathnam, D; Shao, J; Zhang, L; Zhao, J; Wang, Y; Li, T; Mull, E; Enyedy, I; Wang, C; Zhu, Q; Altieri, M; Jordan, J; Dang, TT; Reddy, S Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 15:1973-7 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 3
Synonyms:
ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Homo sapiens (Human)
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
  
Inhibitor
Name:
BDBM50164704
Synonyms:
CHEMBL364935 | N*4*-(3H-Benzoimidazol-5-yl)-N*2*-(4-bromo-phenyl)-5-trifluoromethyl-pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C18H12BrF3N6
Mol. Mass.:
449.227
SMILES:
FC(F)(F)c1cnc(Nc2ccc(Br)cc2)nc1Nc1ccc2nc[nH]c2c1
Structure:
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