Reaction Details
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Synaptic vesicle glycoprotein 2A
Ligand
BDBM50592916
Substrate
n/a
Meas. Tech.
ChEMBL_2206391 (CHEMBL5119099)
Ki
>250000±n/a nM
Citation
Abram, M; Jakubiec, M; Reeb, K; Cheng, MH; Gedschold, R; Rapacz, A; Mogilski, S; Soca?a, K; Nieoczym, D; Szafarz, M; Latacz, G; Szulczyk, B; Kalinowska-T?u?cik, J; Gawel, K; Esguerra, CV; Wyska, E; Müller, CE; Bahar, I; Fontana, ACK; Wla?, P; Kami?ski, RM; Kami?ski, K Discovery of ( J Med Chem 65:11703-11725 (2022) [PubMed] More Info.:
Target
Name:
Synaptic vesicle glycoprotein 2A
Synonyms:
KIAA0736 | SV2A | SV2A_HUMAN
Type:
PROTEIN
Mol. Mass.:
82682.79
Organism:
Homo sapiens
Description:
ChEMBL_120087
Residue:
742
Sequence:
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
Inhibitor
Name:
BDBM50592916
Synonyms:
CHEMBL5206486
Type:
Small organic molecule
Emp. Form.:
C14H16N2O3
Mol. Mass.:
260.2884
SMILES:
C[C@@H](N1C(=O)CCC1=O)C(=O)NCc1ccccc1 |r|
Structure:
